Friday, June 19, 2015
History
Mononucleosis was first discovered in the by Emil Pfeiffer in 1889; However, at this time, the disease was known as glandular fever. Pfeiffer characterized the disease as an infectious disease with symptoms of a fever, swelling of the lymph nodes, enlargement of the spleen, and pharyngitis. In 1920, Sprunt and Evans gave glandular fever the term mononucleosis. Then Paul and Bunnell discovered the presence of heterophil antibodies in mononucleosis in 1932. Mononucleosis was then found to have relations to Epstein-Barr virus (EBV) in 1968 by Henle and Henle. With this connection, the pathogenesis of mononucleosis was soon determined ( Padiatr). These important findings allowed for future research into the clinical course of mononucleosis.
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